Premium
Magnetic‐Nanoparticle‐Doped Carbogenic Nanocomposite: An Effective Magnetic Resonance/Fluorescence Multimodal Imaging Probe
Author(s) -
Srivastava Sachchidanand,
Awasthi Rishi,
Tripathi Deepak,
Rai Mohit K.,
Agarwal Vikas,
Agrawal Vinita,
Gajbhiye Namdeo S.,
Gupta Rakesh K.
Publication year - 2012
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201101863
Subject(s) - nanocomposite , materials science , superparamagnetism , nanoparticle , fluorescence , thermal decomposition , fluorescence lifetime imaging microscopy , magnetic nanoparticles , magnetic resonance imaging , nuclear magnetic resonance , nanotechnology , magnetic field , chemistry , magnetization , optics , organic chemistry , medicine , physics , quantum mechanics , radiology
A novel and facile approach is developed to synthesize a magnetic nanoparticle (iron oxide)‐doped carbogenic nanocomposite (IO‐CNC) for magnetic resonance (MR)/fluorescence imaging applications. IO‐CNC is synthesized by thermal decomposition of organic precursors in the presence of Fe 3 O 4 nanoparticles with an average size of 6 nm. IO‐CNC shows wavelength‐tunable fluorescence properties with high quantum yield. Magnetic studies confirm the superparamagnetic nature of IO‐CNC at room temperature. IO‐CNC shows MR contrast behavior by affecting the proton relaxation phenomena. The measured longitudinal ( r 1 ) and transverse ( r 2 ) relaxivity values are 4.52 and 34.75 m M −1 s −1 , respectively. No apparent cytotoxicity is observed and the nanocomposite shows a biocompatible nature. In vivo MR studies show both T 1 and T 2 * contrast behavior of the nanocomposite. Fluorescence imaging indicates selective uptake of IO‐CNC by macrophages in spleen.