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Bioderived Polyelectrolyte Nanogels for Robust Antigen Loading and Vaccine Adjuvant Effects
Author(s) -
Lim Yong Taik,
Shim SangMu,
Noh YoungWoock,
Lee KyungSoon,
Choi DooYeol,
Uyama Hiroshi,
Bae Hee Ho,
Kim Ji Hyun,
Hong Kwan Soo,
Sung MoonHee,
Poo Haryoung
Publication year - 2011
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201101836
Subject(s) - adjuvant , ovalbumin , polyelectrolyte , antigen , cytotoxic t cell , chemistry , immune system , immunology , biology , biochemistry , in vitro , organic chemistry , polymer
An easy but robust strategy for the synthesis of bioderived polyelectrolyte nanogels for protein antigen loading and vaccine adjuvant systems that can improve both humoral (Th2) and cellular immunity (Th1) is presented. The synthesized polyelectrolyte nanogels promote the uptake of antigens into antigen‐presenting cells and strongly induce ovalbumin‐specific INF‐γ producing cells, cytotoxic T cell activity, and antibody production.