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Branched and 4‐Arm Starlike α ‐Helical Peptide Structures with Enhanced Antimicrobial Potency and Selectivity
Author(s) -
Wiradharma Nikken,
Liu ShaoQiong,
Yang YiYan
Publication year - 2012
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201101672
Subject(s) - antimicrobial , peptide , selectivity , hemolysis , branching (polymer chemistry) , combinatorial chemistry , macromolecule , potency , chemistry , antimicrobial peptides , computational biology , computer science , nanotechnology , biochemistry , in vitro , biology , materials science , organic chemistry , immunology , catalysis
Linear, 2‐arm branched, and 4‐arm starlike peptides are designed and their antimicrobial and hemolytic activities are characterized. Branching molecular designs are demonstrated to enhance antimicrobial activity and reduce undesired hemolysis, leading to better selectivity towards microbes over mammalian cells. This unique strategy can also be applied to optimize the molecular structures of other types of macromolecular antimicrobials such as polymers.