Premium
Hydrogel Nanoparticles with Covalently Linked Coomassie Blue for Brain Tumor Delineation Visible to the Surgeon
Author(s) -
Nie Guochao,
Hah Hoe Jin,
Kim Gwangseong,
Lee YongEun Koo,
Qin Ming,
Ratani Tanvi S.,
Fotiadis Panagiotis,
Miller Amber,
Kochi Akiko,
Gao Di,
Chen Thomas,
Orringer Daniel A.,
Sagher Oren,
Philbert Martin A.,
Kopelman Raoul
Publication year - 2012
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201101607
Subject(s) - covalent bond , in vivo , coomassie brilliant blue , polyethylene glycol , nanoparticle , conjugated system , blue light , staining , materials science , contrast (vision) , chemistry , biophysics , nanotechnology , polymer , pathology , biochemistry , medicine , optics , organic chemistry , biology , optoelectronics , microbiology and biotechnology , physics
Delineation of tumor margins is a critical and challenging objective during brain cancer surgery. A tumor‐targeting deep‐blue nanoparticle‐based visible contrast agent is described, which, for the first time, offers in vivo tumor‐specific visible color staining. This technology thus enables color‐guided tumor resection in real time, with no need for extra equipment or special lighting conditions. The visual contrast agent consists of polyacrylamide nanoparticles covalently linked to Coomassie Blue molecules (for nonleachable blue color contrast), which are surface‐conjugated with polyethylene glycol and F3 peptides for efficient in vivo circulation and tumor targeting, respectively.