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Asymmetric Hybrid Silica Nanomotors for Capture and Cargo Transport: Towards a Novel Motion‐Based DNA Sensor
Author(s) -
Simmchen Juliane,
Baeza Alejandro,
Ruiz Daniel,
Esplandiu Maria José,
ValletRegí Maria
Publication year - 2012
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201101593
Subject(s) - nanodevice , oligonucleotide , nanotechnology , molecular motor , materials science , dna , surface modification , mesoporous silica , cleave , chemistry , mesoporous material , catalysis , biochemistry
An innovative self‐propelled nanodevice able to perform motion, cargo transport, and target recognition is presented. The system is based on a mesoporous motor particle, which is asymmetrically functionalized by the attachment of single‐stranded DNA onto one of its faces, while catalase is immobilized on the other face. This enzyme allows catalytic decomposition of hydrogen peroxide to oxygen and water, giving rise to the driving force for the motion of the whole system. Moreover the motor particles are able to capture and transport cargo particles functionalized with a noncomplementary single‐stranded DNA molecule, only if a specific oligonucleotide sequence is present in the media. Functionalization with characteristic oligonucleotide sequences in the system implies a potential for further developments for lab‐on‐chip devices with applications in biomedical applications.