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Electrospun Fiber Template for Replica Molding of Microtopographical Neural Growth Guidance
Author(s) -
Liu Yingyi,
Sun Yi,
Yan Hao,
Liu Xiyu,
Zhang Wei,
Wang Zhuo,
Jiang Xingyu
Publication year - 2012
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201101199
Subject(s) - polydimethylsiloxane , materials science , replica , molding (decorative) , substrate (aquarium) , microfluidics , nanotechnology , pdms stamp , composite material , fiber , fabrication , art , oceanography , geology , visual arts , medicine , alternative medicine , pathology
A method for replica molding electrospun (ES) fibers on the surface of polydimethylsiloxane (PDMS) is developed for culturing and guiding of cells, instead of ES fibers. With this method, microgrooves and microstructures composed of microgrooves can be obtained. PDMS is integrated into the microfluidic chip as a substrate to successfully pattern and guide neurites on the PDMS surface with microgrooves.