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Nucleic Acid–Gold Nanoparticle Conjugates as Mimics of microRNA
Author(s) -
Hao Liangliang,
Patel Pinal C.,
Alhasan Ali H.,
Giljohann David A.,
Mirkin Chad A.
Publication year - 2011
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201101018
Subject(s) - microrna , nucleic acid , conjugate , colloidal gold , function (biology) , messenger rna , rna , computational biology , nanoparticle , cationic polymerization , nanotechnology , chemistry , combinatorial chemistry , computer science , biology , biochemistry , microbiology and biotechnology , gene , materials science , organic chemistry , mathematical analysis , mathematics
Novel conjugates of gold nanoparticles functionalized with synthetic microRNAs can enter cells without the aid of cationic co‐carriers and mimic the function of endogenous microRNAs. These conjugates can regulate multiple proteins through interactions with the 3′ untranslated region of the target messenger RNA and control cell behavior. The conjugates are promising new tools for studying microRNA function and are candidates for microRNA replacement therapies.