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Detection of Nanoparticle Endocytosis Using Magneto‐Photoacoustic Imaging
Author(s) -
Qu Min,
Mehrmohammadi Mohammad,
Emelianov Stanislav
Publication year - 2011
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201100960
Subject(s) - endocytosis , nanoparticle , photoacoustic imaging in biomedicine , nanotechnology , receptor mediated endocytosis , materials science , drug delivery , computer science , chemistry , cell , biochemistry , optics , physics
The endocytosis of nanoparticles by cells is of significant interest in various biomedical applications, including drug delivery and targeted therapy. An approach is developed to noninvasively detect nanoparticle endocytosis by living cells using magneto‐photoacoustic (MPA) imaging. Using macrophages, it is demonstrated that the nanoparticles endocytosed by cells generate significantly larger MPA signals than the same concentration of nanoparticles present in the vicinity of macrophages. Overall, MPA imaging can simultaneously detect both the delivery and cellular endocytosis of nanoparticles.