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Exploiting Dimerization of Purely Peptidic Amphiphiles to Form Vesicles
Author(s) -
Schuster Thomas B.,
de Bruyn Ouboter Dirk,
Bruns Nico,
Meier Wolfgang
Publication year - 2011
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201100701
Subject(s) - amphiphile , vesicle , peptide , nanotechnology , chemistry , combinatorial chemistry , drug delivery , membrane , computer science , biophysics , materials science , biochemistry , organic chemistry , copolymer , biology , polymer
Short, amphiphilic peptides self‐assemble into vesicles due to dimerization. These additional interactions lead to the formation of stable peptide membranes. The vesicles demonstrate pH responsiveness and the ability to encapsulate hydrophobic and hydrophilic moieties within their structure, and therefore may be used as an advanced, biodegradable, drug‐delivery system.