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Addressing Brain Tumors with Targeted Gold Nanoparticles: A New Gold Standard for Hydrophobic Drug Delivery?
Author(s) -
Cheng Yu,
Meyers Joseph D.,
Agnes Richard S.,
Doane Tennyson L.,
Kenney Malcolm E.,
Broome AnnMarie,
Burda Clemens,
Basilion James P.
Publication year - 2011
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201100628
Subject(s) - library science , molecular imaging , center (category theory) , medicine , nanotechnology , chemistry , computer science , materials science , biology , microbiology and biotechnology , in vivo , crystallography
EGF‐modified Au NP–Pc 4 conjugates showed 10‐fold improved selectivity to the brain tumor compared to untargeted conjugates. The hydrophobic photodynamic therapy drug Pc 4 can be delivered efficiently into glioma brain tumors by EGF peptide‐targeted Au NPs. Compared to the untargeted conjugates, EGF–Au NP–Pc 4 conjugates showed 10‐fold improved selectivity to the brain tumor. This delivery system holds promise for future delivery of a wider range of hydrophobic therapeutic drugs for the treatment of hard‐to‐reach cancers.