Addressing Brain Tumors with Targeted Gold Nanoparticles: A New Gold Standard for Hydrophobic Drug Delivery? | Zendy

Cheng Yu | Zendy; Meyers Joseph D. | Zendy; Agnes Richard S. | Zendy; Doane Tennyson L. | Zendy; Kenney Malcolm E. | Zendy; Broome AnnMarie | Zendy; Burda Clemens | Zendy; Basilion James P. | Zendy

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Addressing Brain Tumors with Targeted Gold Nanoparticles: A New Gold Standard for Hydrophobic Drug Delivery?

Author(s) -

Cheng Yu,

Meyers Joseph D.,

Agnes Richard S.,

Doane Tennyson L.,

Kenney Malcolm E.,

Broome AnnMarie,

Burda Clemens,

Basilion James P.

Publication year - 2011

Publication title -

small

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.785

H-Index - 236

eISSN - 1613-6829

pISSN - 1613-6810

DOI - 10.1002/smll.201100628

Subject(s) - library science , molecular imaging , center (category theory) , medicine , nanotechnology , chemistry , computer science , materials science , biology , microbiology and biotechnology , in vivo , crystallography

EGF‐modified Au NP–Pc 4 conjugates showed 10‐fold improved selectivity to the brain tumor compared to untargeted conjugates. The hydrophobic photodynamic therapy drug Pc 4 can be delivered efficiently into glioma brain tumors by EGF peptide‐targeted Au NPs. Compared to the untargeted conjugates, EGF–Au NP–Pc 4 conjugates showed 10‐fold improved selectivity to the brain tumor. This delivery system holds promise for future delivery of a wider range of hydrophobic therapeutic drugs for the treatment of hard‐to‐reach cancers.

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