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Drug Dissolution Chip (DDC): A Microfluidic Approach for Drug Release
Author(s) -
Windbergs Maike,
Weitz David A.
Publication year - 2011
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201100520
Subject(s) - microfluidics , dissolution , drug , microfluidic chip , drug delivery , dissolution testing , nanotechnology , materials science , organ on a chip , drug development , chromatography , chemistry , pharmacology , medicine , biopharmaceutics classification system
The first pharmaceutical dissolution testing device for multiparticulate drug delivery systems on a microfluidic chip is presented. This versatile platform technology allows for simultaneous analysis of the drug concentration in the dissolution medium and of the solid parts of the sample immobilized in the device with different analytical techniques. By mimicking the fate of drug release in the human body, this can contribute to the optimization of therapeutic effectiveness during the development of novel drug release systems.