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Glyco‐DNA–Gold Nanoparticles: Lectin‐Mediated Assembly and Dual‐Stimuli Response
Author(s) -
Witten Katrin G.,
Rech Claudia,
Eckert Thomas,
Charrak Samir,
Richtering Walter,
Elling Lothar,
Simon Ulrich
Publication year - 2011
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201100492
Subject(s) - dna , lectin , colloidal gold , nanoparticle , biophysics , duplex (building) , dissociation (chemistry) , dna nanotechnology , chemistry , mannan binding lectin , nanotechnology , materials science , biochemistry , biology , organic chemistry
The formation and properties of glyco‐DNA–gold nanoparticles (NP) with a multivalent presentation of DNA‐glyco ligands is presented. These particles are equipped with two reversible binding modes, which enable reversible dissociation by two independent external stimuli: temperature‐induced DNA duplex melting and displacement of the DNA‐glyco ligands from the carbohydrate recognition domains with free sugar.