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Acrylate‐Facilitated Cellular Uptake of Gold Nanoparticles
Author(s) -
Krpetić Željka,
Nativo Paola,
Prior Ian A.,
Brust Mathias
Publication year - 2011
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201100462
Subject(s) - hela , acrylate , colloidal gold , nanoparticle , cytosol , nanotechnology , chemistry , combinatorial chemistry , materials science , cell , biochemistry , copolymer , organic chemistry , polymer , enzyme
Uptake of PEGylated gold nanoparticles by HeLa cells in the presence of acrylate is described. Nanoparticles that are usually not taken up readily cross the plasma membrane into the cytosol in the presence of acrylate. In addition, a method is described that allows the introduction of large amounts of pre‐aggregated gold nanoparticles into the cells without compromising the cell viability.