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More Effective Nanomedicines through Particle Design
Author(s) -
Wang Jin,
Byrne James D.,
Napier Mary E.,
DeSimone Joseph M.
Publication year - 2011
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201100442
Subject(s) - nanomedicine , nanotechnology , biodistribution , nanoparticle , materials science , surface charge , particle (ecology) , chemistry , biochemistry , oceanography , geology , in vitro
Nanomedicine is an emerging field that applies concepts in nanotechnology to develop novel diagnostics and therapies. Physical and chemical properties of particles, including size, shape, modulus, surface charge and surface chemistry, play an important role in determining particle–cell interactions, cellular trafficking mechanisms, biodistribution, and pharmacokinetics. This discussion focuses on both nanoparticles and microparticles since microparticles can also provide many insights for the development of drug carriers and possess advantages over nanoparticles in certain applications. This review covers recent major advancement in the nanomedicine field and also highlights studies using the PRINT technology.