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Selective Detection of Neurotoxin by Photoluminescent Peptide Nanotubes
Author(s) -
Kim Jae Hong,
Ryu Jungki,
Park Chan Beum
Publication year - 2011
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201002107
Subject(s) - photoluminescence , lanthanide , peptide , paraoxon , neurotoxin , materials science , quenching (fluorescence) , selectivity , nanotechnology , nitro , photochemistry , combinatorial chemistry , chemistry , ion , organic chemistry , catalysis , fluorescence , biochemistry , optoelectronics , physics , alkyl , quantum mechanics , acetylcholinesterase , enzyme
Photoluminescent peptide nanotubes undergo a drastic quenching of their emission within a few seconds of exposure to paraoxon, a nitro‐functionalized neurotoxin. The photoluminescence quenching occurs due to the interruption of cascaded energy transfer from peptide nanotubes to lanthanide ions. The assay platform provides high selectivity toward paraoxon, among other organophosphates, nitro‐group compounds, and common organic chemicals; this capability is attributed to the role of the diphenylalanine nanotubes as a host matrix for lanthanide complexes.