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Engineering, Characterization and Directional Self‐Assembly of Anisotropically Modified Nanocolloids
Author(s) -
Bhaskar Srijanani,
Gibson Christopher T.,
Yoshida Mutsumi,
Nandivada Himabindu,
Deng Xiaopei,
Voelcker Nicolas H.,
Lahann Joerg
Publication year - 2011
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201001695
Subject(s) - acetylene , polymer , materials science , polymerization , click chemistry , nanotechnology , raman spectroscopy , chemical engineering , chemical vapor deposition , streptavidin , polymer chemistry , chemistry , biotin , organic chemistry , biochemistry , physics , optics , composite material , engineering
Abstract Along with traditional attributes such as the size, shape, and chemical structure of polymeric micro‐objects, control over material distribution, or selective compartmentalization, appears to be increasingly important for maximizing the functionality and efficacy of biomaterials. The fabrication of tri‐ and tetracompartmental colloids made from biodegradable poly(lactide‐co‐glycolide) polymers via electrohydrodynamic co‐jetting is demonstrated. The presence of three compartments is confirmed via flow cytometry. Additional chemical functionality is introduced via the incorporation of acetylene‐functionalized polymers into individual compartments of the particles. Direct visualization of the spatioselective distribution of acetylene groups is demonstrated by confocal Raman microscopy as well as by reaction of the acetylene groups with azide‐biotin via ‘click chemistry’. Biotin–streptavidin binding is then utilized for the controlled assembly and orientation of bicompartmental particles onto functionalized, micropatterned substrates prepared via chemical vapor deposition polymerization.