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Intact Mammalian Cell Function on Semiconductor Nanowire Arrays: New Perspectives for Cell‐Based Biosensing
Author(s) -
Berthing Trine,
Bonde Sara,
Sørensen Claus B.,
Utko Pawel,
Nygård Jesper,
Martinez Karen L.
Publication year - 2011
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201001642
Subject(s) - intracellular , microbiology and biotechnology , dorsal root ganglion , cell , nanowire , embryonic stem cell , nanotechnology , cytosol , cell adhesion , materials science , gallium arsenide , indium arsenide , membrane , biophysics , chemistry , biology , enzyme , quantum dot , optoelectronics , dorsum , biochemistry , anatomy , gene
Nanowires (NWs) are attracting more and more interest due to their potential cellular applications, such as delivery of compounds or sensing platforms. Arrays of vertical indium‐arsenide (InAs) NWs are interfaced with human embryonic kidney cells and rat embryonic dorsal root ganglion neurons. A selection of critical cell functions and pathways are shown not to be impaired, including cell adhesion, membrane integrity, intracellular enzyme activity, DNA uptake, cytosolic and membrane protein expression, and the neuronal maturation pathway. The results demonstrate the low invasiveness of InAs NW arrays, which, combined with the unique physical properties of InAs, open up their potential for cellular investigations.