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Efficient Cytosolic Delivery of siRNA Using HDL‐Mimicking Nanoparticles
Author(s) -
Yang Mi,
Jin Honglin,
Chen Juan,
Ding Lili,
Ng Kenneth K.,
Lin Qiaoya,
Lovell Jonathan F.,
Zhang Zhihong,
Zheng Gang
Publication year - 2011
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201001589
Subject(s) - nanocarriers , small interfering rna , rna interference , cytosol , nanoparticle , biocompatible material , microbiology and biotechnology , chemistry , phospholipid , biophysics , nanotechnology , rna , materials science , biochemistry , biology , membrane , medicine , biomedical engineering , gene , enzyme
High‐density lipoprotein (HDL)‐mimicking peptide–phospholipid scaffold (HPPS) nanoparticles are used as a flexible and biocompatible nanocarrier for the delivery of small interfering RNA (siRNA). The direct cytosolic delivery ability of cholesterol‐modified siRNA displayed by the nanoparticle results in the selective delivery of RNA interference (RNAi) to targeted cells. This provides a strategy to bypass endolysosomal trafficking, and makes HPPS a useful tool for therapeutic siRNA delivery.