Enhanced Chemotherapy Efficacy by Sequential Delivery of siRNA and Anticancer Drugs Using PEI‐Grafted Graphene Oxide | Zendy

Zhang Liming | Zendy; Lu Zhuoxuan | Zendy; Zhao Qinghuan | Zendy; Huang Jie | Zendy; Shen He | Zendy; Zhang Zhijun | Zendy

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Enhanced Chemotherapy Efficacy by Sequential Delivery of siRNA and Anticancer Drugs Using PEI‐Grafted Graphene Oxide

Author(s) -

Zhang Liming,

Lu Zhuoxuan,

Zhao Qinghuan,

Huang Jie,

Shen He,

Zhang Zhijun

Publication year - 2011

Publication title -

small

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.785

H-Index - 236

eISSN - 1613-6829

pISSN - 1613-6810

DOI - 10.1002/smll.201001522

Subject(s) - polyethylenimine , nanocarriers , doxorubicin , graphene , gene knockdown , small interfering rna , conjugated system , oxide , drug delivery , nanotechnology , anticancer drug , chemistry , chemotherapy , pharmacology , drug , materials science , rna , medicine , biochemistry , gene , polymer , surgery , transfection , organic chemistry

Loading and delivery of Bcl‐2‐targeted short interfering RNA (siRNA) and anticancer drug doxorubicin (DOX) by polyethylenimine (PEI)‐conjugated graphene oxide (PEI‐GO) is studied. A higher knockdown efficiency of siRNA delivered by PEI‐GO than by PEI is achieved. Sequential delivery of siRNA and DOX by the PEI‐GO nanocarrier shows a synergistic effect, which leads to significantly improved chemotherapy efficacy.

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