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Enhanced Chemotherapy Efficacy by Sequential Delivery of siRNA and Anticancer Drugs Using PEI‐Grafted Graphene Oxide
Author(s) -
Zhang Liming,
Lu Zhuoxuan,
Zhao Qinghuan,
Huang Jie,
Shen He,
Zhang Zhijun
Publication year - 2011
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201001522
Subject(s) - polyethylenimine , nanocarriers , doxorubicin , graphene , gene knockdown , small interfering rna , conjugated system , oxide , drug delivery , nanotechnology , anticancer drug , chemistry , chemotherapy , pharmacology , drug , materials science , rna , medicine , biochemistry , gene , polymer , surgery , transfection , organic chemistry
Loading and delivery of Bcl‐2‐targeted short interfering RNA (siRNA) and anticancer drug doxorubicin (DOX) by polyethylenimine (PEI)‐conjugated graphene oxide (PEI‐GO) is studied. A higher knockdown efficiency of siRNA delivered by PEI‐GO than by PEI is achieved. Sequential delivery of siRNA and DOX by the PEI‐GO nanocarrier shows a synergistic effect, which leads to significantly improved chemotherapy efficacy.