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Facile Preparation of a Hybrid Nanoprobe for Triple‐Modality Optical/PET/MR Imaging
Author(s) -
Park Jeong Chan,
Yu Mi Kyung,
An Gwang Il,
Park SeIl,
Oh Jungmin,
Kim Hong Joo,
Kim JooHyun,
Wang Eun Kyung,
Hong IlHwa,
Ha Yeong Su,
Choi Tae Hyun,
Jeong KyuShik,
Chang Yongmin,
Welch Michael J.,
Jon Sangyong,
Yoo Jeongsoo
Publication year - 2010
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201001418
Subject(s) - nanoprobe , modality (human–computer interaction) , optical imaging , superparamagnetism , computer science , molecular imaging , nanotechnology , materials science , medical physics , nuclear medicine , nanoparticle , artificial intelligence , medicine , physics , optics , magnetization , quantum mechanics , magnetic field , microbiology and biotechnology , in vivo , biology
A facile method of preparing triple‐modality , optical–nuclear–magnetic imaging probes using radiolabeled superparamagnetic nanoparticles is developed. Cerenkov luminescence imaging based on radionuclides showed great potential as a new optical imaging modality. The complementary nature of the optical/PET/MR hybrid nanoprobes facilitated non‐invasive differentiation between tumor‐metastasized sentinel lymph nodes (SLNs) and tumor‐free SLNs.