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Engineering Nanocarriers for siRNA Delivery
Author(s) -
Tan Shawn J.,
Kiatwuthi Pichamon,
Roh Young Hoon,
Kahn Jason S.,
Luo Dan
Publication year - 2011
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201001389
Subject(s) - nanocarriers , biocompatible material , nanotechnology , small interfering rna , rna interference , materials science , drug delivery , medicine , chemistry , biomedical engineering , rna , gene , biochemistry
The discovery of RNA interference has revitalized the long ongoing pursuit of gene therapy for the treatment of diseases. Nevertheless, despite promising results from experimental studies, there remains a pressing need for the development of nanocarriers that are clinically‐relevant, biocompatible, efficient, and that can be tailored to specific disease targets. This review surveys the broad spectrum of nanomaterials and their functional add‐ons, and aims to provide a guide towards engineering nanocarriers for effective siRNA delivery.