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Cell Response to Carbon Nanotubes: Size‐Dependent Intracellular Uptake Mechanism and Subcellular Fate
Author(s) -
Kang Bin,
Chang Shuquan,
Dai Yaodong,
Yu Decai,
Chen Da
Publication year - 2010
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201001260
Subject(s) - carbon nanotube , intracellular , cytoplasm , nanotechnology , carbon fibers , materials science , nucleus , cell size , biophysics , cell , mechanism (biology) , chemistry , physics , biochemistry , microbiology and biotechnology , composite material , biology , quantum mechanics , composite number
The intracellular uptake and subcellular localization of carbon nanotubes strongly depend on the physical size of the materials. Multiwalled carbon nanotubes (MWNTs; 0.5–2 μm in length, 10–30 nm in diameter) are excluded from the interior of the cell; long single‐walled carbon nanotubes (L‐SWNTs) of length 100–200 nm (1–3 nm in diameter) are only internalized into cytoplasm, whereas short ones (S‐SWNTs) of length 50–100 nm partly reside in the cell nucleus.