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pH‐Sensitive Nanoflash for Tumoral Acidic pH Imaging in Live Animals
Author(s) -
Ko Jin Young,
Park Sangjin,
Lee Hyejung,
Koo Heebeom,
Kim Min Sang,
Choi Kuiwon,
Kwon Ick Chan,
Jeong Seo Young,
Kim Kwangmeyung,
Lee Doo Sung
Publication year - 2010
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201001252
Subject(s) - micelle , copolymer , fluorescence , in vivo , alkyl , chemistry , in vitro , biophysics , nuclear chemistry , materials science , polymer , organic chemistry , aqueous solution , biochemistry , optics , biology , physics , microbiology and biotechnology
Block‐copolymer micelles are synthesized with specific pH sensitivity according to the alkyl chain length of an amino ester and the encapsulated fluorescent dye and black hole quencher. These quenched nanosized micelles (nanoflashes) present noticeable fluorescence signal amplifications according to the target tumoral acidic pH value in vitro and in vivo.