An On‐Nanoparticle Rolling‐Circle Amplification Platform for Ultrasensitive Protein Detection in Biological Fluids | Zendy

Yan Juan | Zendy; Song Shiping | Zendy; Li Bing | Zendy; Zhang Qingzhi | Zendy; Huang Qing | Zendy; Zhang Hua | Zendy; Fan Chunhai | Zendy

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An On‐Nanoparticle Rolling‐Circle Amplification Platform for Ultrasensitive Protein Detection in Biological Fluids

Author(s) -

Yan Juan,

Song Shiping,

Li Bing,

Zhang Qingzhi,

Huang Qing,

Zhang Hua,

Fan Chunhai

Publication year - 2010

Publication title -

small

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.785

H-Index - 236

eISSN - 1613-6829

pISSN - 1613-6810

DOI - 10.1002/smll.201001220

Subject(s) - carcinoembryonic antigen , rolling circle replication , nanoparticle , biological fluids , computational biology , nanotechnology , computer science , chemistry , microbiology and biotechnology , chromatography , biology , gene , materials science , biochemistry , cancer , genetics , dna replication

An on‐nanoparticle rolling‐circle amplification (nanoRCA) strategy allows the visual detection of 30 molecules of carcinoembryonic antigen with at least 10 10 ‐fold selectivity over a range of noncognate proteins. The nanoRCA assay is applicable to the detection of two tumor markers in biological fluids: prostate‐specific antigen in spiked sera and interleukin‐8 in saliva.

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