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Self‐Assembled Hybrid Structures of DNA Block‐Copolymers and Nanoparticles with Enhanced DNA Binding Properties
Author(s) -
Chen XiJun,
SanchezGaytan Brenda L.,
Hayik Sara E. N.,
Fryd Michael,
Wayland Bradford B.,
Park SoJung
Publication year - 2010
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201001185
Subject(s) - copolymer , dna , self assembly , materials science , nanoparticle , nanotechnology , chemistry , polymer , biochemistry , composite material
The self‐assembly of DNA block‐copolymers and nanoparticles yields hybrid nanostructures with useful properties of incorporated nanoparticles and a high density DNA layer on the exterior. Remarkably, they exhibit drastically enhanced binding capability to complementary DNA even at very low salt concentrations where isolated DNA strands do not form duplex structure. This extraordinary binding capability along with the high selectivity allows for efficient duplex DNA detection.