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Nanofibrous Bio‐inorganic Hybrid Structures Formed Through Self‐Assembly and Oriented Mineralization of Genetically Engineered Phage Nanofibers
Author(s) -
He Tao,
Abbineni Gopal,
Cao Binrui,
Mao Chuanbin
Publication year - 2010
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201001108
Subject(s) - hybrid material , biomineralization , nanofiber , cationic polymerization , materials science , electrospinning , self assembly , polymer , nanotechnology , nanoparticle , hydroxylapatite , chemical engineering , chemistry , polymer chemistry , organic chemistry , composite material , engineering , enzyme
Filamentous M13 phage is genetically engineered to become anionic by fusing a negatively charged peptide to its major coat protein (pVIII). The cationic precursors of hydroxylapatite (HAP) such as Ca 2+ ions induce the self‐assembly of the negatively charged phage into a nanofibrous structure in the presence of anionic precursors such as PO 4 3− ions. The cationic and anionic precursors are accumulated within the nanofibrous structure, leading to the formation of oriented nanocrystalline HAP.