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Dynamic Visualization of RGD‐Quantum Dot Binding to Tumor Neovasculature and Extravasation in Multiple Living Mouse Models Using Intravital Microscopy
Author(s) -
Smith Bryan Ronain,
Cheng Zhen,
De Abhijit,
Rosenberg Jarrett,
Gambhir Sanjiv Sam
Publication year - 2010
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201001022
Subject(s) - extravasation , medicine , medical physics , library science , computer science , pathology
The behavior of targeted quantum dots (Qdots) across three different tumor models using intravital microscopy with submicrometer resolution is described. As in the figure, the differences in extravasation between tumor types are shown and the kinetics are quatnified. Further, by demonstrating similarity in Qdot binding to tumor blood vessels across different tumor types, this work suggests several advantages implicit in vascular targeting compared with tumor cell targeting.