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Surface Properties Dictate Uptake, Distribution, Excretion, and Toxicity of Nanoparticles in Fish
Author(s) -
Zhu ZhengJiang,
Carboni Rachel,
Quercio Michael J.,
Yan Bo,
Miranda Oscar R.,
Anderton Douglas L.,
Arcaro Kathleen F.,
Rotello Vincent M.,
Vachet Richard W.
Publication year - 2010
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201000989
Subject(s) - fish <actinopterygii> , nanomaterials , monolayer , nanoparticle , colloidal gold , nanotechnology , distribution (mathematics) , cationic polymerization , toxicity , chemistry , environmental chemistry , biology , materials science , fishery , organic chemistry , mathematics , mathematical analysis
Monolayer‐protected gold nanoparticles (AuNPs) were used to demonstrate how surface chemistry influences the uptake, distribution, and excretion of nanomaterials in Japanese medaka fish. Hydrophilic AuNPs were found primarily in the fish intestines, showing no obvious health effects on the fish. Hydrophobic cationic AuNPs has a broad distribution in fish organs and lead ultimately to fish mortality in < 24 h.