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Inhibition of Hydroxyapatite Nanoparticle‐Induced Osteogenic Activity in Skeletal Cells by Adsorption of Serum Proteins
Author(s) -
Hails Lauren A.,
Babister Jodie C.,
Inglis Stefanie,
Davis Sean A.,
Oreffo Richard O. C.,
Mann Stephen
Publication year - 2010
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201000939
Subject(s) - nanoparticle , endocytosis , stromal cell , adsorption , chemistry , nanotechnology , biochemistry , materials science , medicine , cell , pathology , organic chemistry
Stimulation of osteogenesis in human bone marrow stromal cells by surface attachment and endocytosis of arginine‐functionalized hydroxyapatite nanoparticles is enhanced when serum proteins are omitted from the culture medium for an initial 24 hour period. This effect, which is related to nanoparticle binding of the serum proteins, could be an important consideration in nanoparticle‐induced bioactivity and nanotoxicity in general.