A DNA‐Origami Chip Platform for Label‐Free SNP Genotyping Using Toehold‐Mediated Strand Displacement | Zendy

Zhang Zhao | Zendy; Zeng Dongdong | Zendy; Ma Hongwei | Zendy; Feng Guoying | Zendy; Hu Jun | Zendy; He Lin | Zendy; Li Can | Zendy; Fan Chunhai | Zendy

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A DNA‐Origami Chip Platform for Label‐Free SNP Genotyping Using Toehold‐Mediated Strand Displacement

Author(s) -

Zhang Zhao,

Zeng Dongdong,

Ma Hongwei,

Feng Guoying,

Hu Jun,

He Lin,

Li Can,

Fan Chunhai

Publication year - 2010

Publication title -

small

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.785

H-Index - 236

eISSN - 1613-6829

pISSN - 1613-6810

DOI - 10.1002/smll.201000908

Subject(s) - genotyping , snp genotyping , dna , snp , single nucleotide polymorphism , chip , nanotechnology , molecular inversion probe , dna microarray , computational biology , biology , genetics , materials science , genotype , computer science , gene , telecommunications , gene expression

A DNA‐origami chip platform for target‐labeling‐free single‐nucleotide polymorphism (SNP) genotyping is presented. DNA capture probes are anchored on an asymmetric map‐shaped DNA‐origami chip and a “toehold”‐mediated strand‐displacement reaction is employed to endow single‐base‐mismatch differentiation specificity. This design leads to a reliable and potentially universal means for SNP genotyping.

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