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Polyhydroxy Fullerenes for Non‐Invasive Cancer Imaging and Therapy
Author(s) -
Krishna Vijay,
Singh Amit,
Sharma Parvesh,
Iwakuma Nobutaka,
Wang Qiang,
Zhang Qizhi,
Knapik Jacquelyn,
Jiang Huabei,
Grobmyer Stephen R.,
Koopman Ben,
Moudgil Brij
Publication year - 2010
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201000847
Subject(s) - photoacoustic imaging in biomedicine , fullerene , cancer imaging , cancer therapy , nanotechnology , optical imaging , materials science , cancer , medicine , biomedical engineering , medical physics , chemistry , optics , physics , organic chemistry
The novel optical properties of polyhydroxy fullerenes (PHF) —which are water‐soluble, biodegradable and antioxidant—are applied for imaging and therapy of cancer. Tumors injected with PHF are imaged with photoacoustic tomography (PAT) and photothermally treated with near‐infrared (NIR) laser. Tumor size decreases up to 72% within two hours of treatment, with only a blister visible after 20 hours.