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Magnetic Luminescent Porous Silicon Microparticles for Localized Delivery of Molecular Drug Payloads
Author(s) -
Gu Luo,
Park JiHo,
Duong Kim H.,
Ruoslahti Erkki,
Sailor Michael J.
Publication year - 2010
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201000841
Subject(s) - materials science , porous silicon , nanotechnology , magnetic nanoparticles , drug delivery , calcein , nanoparticle , silicon , membrane , chemistry , optoelectronics , biochemistry
Magnetic manipulation, fluorescent tracking, and localized delivery of a drug payload to cancer cells in vitro is demonstrated, using nanostructured porous silicon microparticles as a carrier. The multifunctional microparticles are prepared by electrochemical porosification of a silicon wafer in a hydrofluoric acid‐containing electrolyte, followed by removal and fracture of the porous layer into particles using ultrasound. The intrinsically luminescent particles are loaded with superparamagnetic iron oxide nanoparticles and the anti‐cancer drug doxorubicin. The drug‐containing particles are delivered to human cervical cancer (HeLa) cells in vitro, under the guidance of a magnetic field. The high concentration of particles in the proximity of the magnetic field results in a high concentration of drug being released in that region of the Petri dish, and localized cell death is confirmed by cellular viability assay (Calcein AM).