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DNAsomes: Multifunctional DNA‐Based Nanocarriers
Author(s) -
Roh Young Hoon,
Lee Jong Bum,
Kiatwuthi Pichamon,
Hartman Mark R.,
Cha Judy J.,
Um Soong Ho,
Muller David A.,
Luo Dan
Publication year - 2011
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201000752
Subject(s) - nanocarriers , nucleic acid , dna , rna , liposome , small interfering rna , computational biology , nanotechnology , amphiphile , base pair , chemistry , drug delivery , biology , computer science , gene , biochemistry , materials science , polymer , organic chemistry , copolymer
Multifunctional DNAsomes: DNA–lipid amphiphiles self‐assemble into novel “DNAsomes”—liposome‐like core–shell structures with subunits composed of branched DNA–lipid hybrid molecules. These DNAsomes can be precisely tuned over a wide range in terms of both size and surface charge. More importantly, DNAsome is a natural carrier of small interfering RNA (siRNA) due to DNA–RNA base‐pairing, enabling efficient co‐delivery of drugs and siRNA. The DNAsome represents a universal multifunctional drug vector for simultaneous delivery of drugs, tracer dyes, or antibodies, along with genes, siRNA, or antisense nucleic acids.