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Apoptotic Cell Imaging Using Phosphatidylserine‐Specific Receptor‐Conjugated Ru(bpy) 3 2+ ‐Doped Silica Nanoparticles
Author(s) -
Bae Se Won,
Cho Min Sun,
Jeong A Reum,
Choi BoRa,
Kim DongEun,
Yeo WoonSeok,
Hong JongIn
Publication year - 2010
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201000564
Subject(s) - conjugated system , phosphatidylserine , nanoparticle , materials science , doping , apoptosis , crystallography , nanotechnology , chemistry , optoelectronics , biochemistry , polymer , phospholipid , membrane , composite material
Ru(bpy) 3 2+ ‐doped silica nanoparticles surface‐functionalized with a phosphatidylserine‐selective synthetic ligand are designed for the purpose of detecting and imaging apoptotic cells (see image). The preferential binding of this ligand to phosphatidylserine in preference to other phospholipids is confirmed and the ligands are conjugated onto the highly fluorescent and biocompatible Ru(bpy) 3 2+ ‐doped silica nanoparticles in a multivalent fashion.