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Single‐Cell‐Level Cancer Therapy Using a Hollow Optical Fiber‐Based Microplasma
Author(s) -
Kim Jae Young,
Ballato John,
Foy Paul,
Hawkins Thomas,
Wei Yanzhang,
Li Jinhua,
Kim SungO
Publication year - 2010
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201000480
Subject(s) - microplasma , materials science , plasma , cancer cell , jet (fluid) , nanotechnology , cell , apoptosis , cancer , cancer research , optoelectronics , chemistry , medicine , biochemistry , physics , quantum mechanics , thermodynamics
A flexible microplasma jet device with a hollow‐core optical fiber produces a plasma plume that is quite narrow but long enough to apply direct treatment to single‐tumor cells. The microplasma induces apoptosis in murine melanoma cells in a dose‐dependent manner, and under certain conditions can selectively destroy tumor cells with no harm to murine fibroblasts