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Fabrication of Gold Nanoparticles Inside Unmodified Horse Spleen Apoferritin
Author(s) -
Fan Rongli,
Chew Shu Wen,
Cheong Vee Vee,
Orner Brendan Patrick
Publication year - 2010
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201000457
Subject(s) - nanocages , nanoclusters , ferritin , dispersity , nanoparticle , materials science , colloidal gold , nanotechnology , characterization (materials science) , horse , chemical engineering , chemistry , polymer chemistry , organic chemistry , biochemistry , biology , catalysis , paleontology , engineering
Size‐constrained gold nanoparticles are successfully synthesized within the cavity of native horse spleen ferritin by using a two‐step process relying on the initial formation of nanoclusters. The particles co‐elute with the nanocage ferritin by chromatography, indicating that the particles are associated with intact protein cages. Further characterization reveals that the growth of the monodisperse particles is limited by the protein cage.