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Examination of Folate‐Targeted Liposomes with Encapsulated Poly(2‐propylacrylic acid) as a pH‐Responsive Nanoplatform for Cytosolic Drug Delivery
Author(s) -
Cheng Zhiliang,
Chen Antony K.,
Lee HaYoung,
Tsourkas Andrew
Publication year - 2010
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201000347
Subject(s) - liposome , cytosol , drug delivery , folic acid , chemistry , folate receptor , targeted drug delivery , membrane , combinatorial chemistry , drug , small molecule , biochemistry , nanotechnology , biophysics , pharmacology , enzyme , medicine , materials science , biology , organic chemistry , cancer cell , cancer
Cells are incubated with folate‐targeted liposomes formed in the presence or absence of poly(2‐propylacrylic acid) (PPAA). The pH‐responsive nature of liposomes with encapsulated PPAA allows for the efficient delivery of membrane‐impermeable molecules, such as anticancer drugs, into the cytosol of living cells.