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Preparation of Stable Maleimide‐Functionalized Au Nanoparticles and Their Use in Counting Surface Ligands
Author(s) -
Oh E.,
Susumu K.,
BlancoCanosa J. B.,
Medintz I. L.,
Dawson P. E.,
Mattoussi H.
Publication year - 2010
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201000279
Subject(s) - maleimide , ethylene glycol , nanoparticle , combinatorial chemistry , ligand (biochemistry) , colloidal gold , chemistry , thioctic acid , thiol , nanotechnology , polymer chemistry , materials science , organic chemistry , biochemistry , receptor , lipoic acid , antioxidant
A modular ligand made of poly(ethylene glycol) appended with a thioctic acid anchoring group at one end and a maleimide at the other is synthesized and used to prepare maleimide‐functionalized gold nanoparticles (AuNPs). This design allows effective conjugation of AuNPs to peptide‐dye via maleimide–thiol coupling. By tuning the fraction of maleimides per NP the number of surface ligands per AuNP can be estimated.