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Aptatag‐Based Multiplexed Assay for Protein Detection by Surface‐Enhanced Raman Spectroscopy
Author(s) -
Fabris Laura,
Schierhorn Martin,
Moskovits Martin,
Bazan Guillermo C.
Publication year - 2010
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201000262
Subject(s) - aptamer , polyethylene glycol , raman spectroscopy , surface enhanced raman spectroscopy , multiplexing , selectivity , protein detection , materials science , nanoparticle , dna , colloidal gold , bioassay , nanotechnology , chemistry , chromatography , microbiology and biotechnology , raman scattering , biochemistry , optics , biology , physics , electrical engineering , genetics , engineering , catalysis
Silver‐nanoparticle dimers held together by a Raman reporter, capped with DNA aptamers and stabilized by polyethylene glycol chains, can be used to develop a multiplexed heterogeneous bioassay for protein detection with high sensitivity and selectivity.