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Constraint of DNA on Functionalized Graphene Improves its Biostability and Specificity
Author(s) -
Tang Zhiwen,
Wu Hong,
Cort John R.,
Buchko Garry W.,
Zhang Youyu,
Shao Yuyan,
Aksay Ilhan A.,
Liu Jun,
Lin Yuehe
Publication year - 2010
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201000024
Subject(s) - graphene , constraint (computer aided design) , materials science , dna , nanotechnology , computer science , mathematical optimization , chemistry , mathematics , engineering , mechanical engineering , biochemistry
Single‐stranded DNA constrained on a graphene surface is effectively protected from enzymatic cleavage by DNase I. Various spectroscopy studies suggest that the single‐stranded DNA is promptly adsorbed onto graphene forming strong molecular interactions. Constraint of the DNA probe on the graphene surface improves the specificity of its response to complementary DNA.