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Magnetite‐Nanoparticle‐Encapsulated pH‐Responsive Polymeric Micelle as an MRI Probe for Detecting Acidic Pathologic Areas
Author(s) -
Gao Guang Hui,
Im Geun Ho,
Kim Min Sang,
Lee Jae Won,
Yang Jehoon,
Jeon Hyesung,
Lee Jung Hee,
Lee Doo Sung
Publication year - 2010
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200902317
Subject(s) - micelle , nanoparticle , magnetite , materials science , magnetite nanoparticles , mri contrast agent , nanotechnology , magnetic resonance imaging , magnetic nanoparticles , chemistry , aqueous solution , organic chemistry , medicine , radiology , metallurgy
A facile and powerful pH‐responsive polymeric micelle encapsulates Fe 3 O 4 nanoparticles as an acid‐targeting MRI contrast agent for pathologic diagnosis. This MRI probe remains in a micellar state in the physiological environment whereas it can be dissolved in acidic pathological areas. More biomedical applications will be possible owing to its unique ability to target an acidic pathologic environment.