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Liposome Destabilization by a 2,7‐Diazapyrenium Derivative Through Formation of Transient Pores in the Lipid Bilayer
Author(s) -
Zappacosta Romina,
Semeraro Monica,
Baroncini Massimo,
Silvi Serena,
Aschi Massimiliano,
Credi Alberto,
Fontana Antonella
Publication year - 2010
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200902306
Subject(s) - popc , liposome , bilayer , lipid bilayer , biophysics , fluorescence , molecule , electron acceptor , acceptor , chemistry , photochemistry , materials science , chemical physics , membrane , nanotechnology , organic chemistry , biochemistry , condensed matter physics , physics , quantum mechanics , biology
The effect of the luminescent heteroaromatic electron acceptor N,N′‐dimethyl‐2,7‐diazapyrenium dichloride (DM‐DAP 2+ ) on the stability of 1‐palmitoyl‐2‐oleoylphosphatydilcholine (POPC) liposomes is determined on the basis of the rate of release of different fluorescent probes entrapped within the liposome. The experiments show that DM‐DAP 2+ exerts a substantial destabilizing action on the liposomal bilayer, particularly at low concentrations. Molecular dynamics simulations suggest that the activity of DM‐DAP 2+ is related to its tendency to surround itself with water molecules, conceivably favoring the formation of transient pores across the bilayer.