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Encoded Multichromophore Response for Simultaneous Label‐Free Detection
Author(s) -
Pistol Constantin,
Mao Vincent,
Thusu Viresh,
Lebeck Alvin R.,
Dwyer Chris
Publication year - 2010
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200901996
Subject(s) - interfacing , biomolecule , electronic circuit , logic gate , nanotechnology , synthetic biology , computer science , materials science , computer hardware , algorithm , electrical engineering , bioinformatics , engineering , biology
Abstract The self‐assembly of molecularly precise nanostructures is widely expected to form the basis of future high‐speed integrated circuits, but the technologies suitable for such circuits are not well understood. In this work, DNA self‐assembly is used to create molecular logic circuits that can selectively identify specific biomolecules in solution by encoding the optical response of near‐field coupled arrangements of chromophores. The resulting circuits can detect label‐free, femtomole quantities of multiple proteins, DNA oligomers, and small fragments of RNA in solution via ensemble optical measurements. This method, which is capable of creating multiple logic‐gate–sensor pairs on a 2 × 80 × 80‐nm DNA grid, is a step toward more sophisticated nanoscale logic circuits capable of interfacing computers with biological processes.