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Mapping Local pH in Live Cells Using Encapsulated Fluorescent SERS Nanotags
Author(s) -
Pallaoro Alessia,
Braun Gary B.,
Reich Norbert. O.,
Moskovits Martin
Publication year - 2010
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200901893
Subject(s) - fluorescence , raman spectroscopy , molecule , photochemistry , particle (ecology) , materials science , chemistry , analytical chemistry (journal) , nanotechnology , chromatography , optics , organic chemistry , biology , physics , ecology
Small Ag clusters incorporating both the pH‐sensitive Raman probe molecule 4‐mercaptobenzoic acid and a fluorescent dye are used to determine the local pH from the spatially mapped surface‐enhanced Raman spectra correlated with the fluorescence, allowing simultaneous single‐particle tracking and local pH sensing.

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