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SERS‐Based Diagnosis and Biodetection
Author(s) -
AlvarezPuebla Ramón A.,
LizMarzán Luis M.
Publication year - 2010
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200901820
Subject(s) - nanotechnology , context (archaeology) , raman scattering , materials science , identification (biology) , optical sensing , raman spectroscopy , biology , physics , optics , optoelectronics , paleontology , botany
Surface‐enhanced Raman scattering (SERS) spectroscopy is one of the most powerful analytical techniques for identification of molecular species, with the potential to reach single‐molecule detection under ambient conditions. This Concept article presents a brief introduction and discussion of both recent advances and limitations of SERS in the context of diagnosis and biodetection, ranging from direct sensing to the use of encoded nanoparticles, in particular focusing on ultradetection of relevant bioanalytes, rapid diagnosis of diseases, marking of organelles within individual cells, and non‐invasive tagging of anomalous tissues in living animals.