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Functional Single‐Virus–Polyelectrolyte Hybrids Make Large‐Scale Applications of Viral Nanoparticles More Efficient
Author(s) -
Wang Xiaoyu,
Deng Yongqiang,
Shi Hongyan,
Mei Zhu,
Zhao Hui,
Xiong Wei,
Liu Peng,
Zhao Yu,
Qin Chengfeng,
Tang Ruikang
Publication year - 2010
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200901795
Subject(s) - polyelectrolyte , nanoparticle , nanotechnology , nanoscopic scale , virus , layer (electronics) , scale (ratio) , materials science , computer science , chemistry , biology , virology , physics , polymer , composite material , quantum mechanics
Single enveloped viruses can be prepared on a large scale with high efficiency by a layer‐by‐layer method. The virus/polyelectrolyte core/shell nanoparticles (VCSPs) exhibit unique characteristics, such as direct observation by electron microscopy without staining, easy separation and concentration, rapid perinuclear delivery, and improved biological safety, which resolve the conventional shortcomings of viruses in nanoscale applications.