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Sustained Drug Release from Non‐eroding Nanoporous Templates
Author(s) -
Gultepe Evin,
Nagesha Dattatri,
Casse Bernard D. F.,
Banyal Ravinder,
Fitchorov Trifon,
Karma Alain,
Amiji Mansoor,
Sridhar Srinivas
Publication year - 2010
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200901736
Subject(s) - nanoporous , materials science , drug delivery , oxide , anodic aluminum oxide , template , kinetics , nanotechnology , anode , drug , desorption , phase (matter) , doxorubicin , chemical engineering , adsorption , chemistry , pharmacology , fabrication , electrode , metallurgy , organic chemistry , medicine , alternative medicine , physics , surgery , pathology , quantum mechanics , chemotherapy , engineering
Nanoporous oxide coatings , such as anodic aluminum oxide (AAO), are utilized as drug‐release platforms for up to weeks of delivery (see picture for doxorubicin, Dox). A burst‐release phase is followed by sustained release, the kinetics of which is described by an activated surface‐density‐dependent desorption model.