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Bioinspired Nanocorals with Decoupled Cellular Targeting and Sensing Functionality
Author(s) -
Wu Liz Y.,
Ross Benjamin M.,
Hong SoonGweon,
Lee Luke P.
Publication year - 2010
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200901604
Subject(s) - nanotechnology , nanosensor , adsorption , polystyrene , computer science , materials science , chemistry , polymer , organic chemistry , composite material
Nanocorals demonstrate independent cell‐targeting and label‐free biomolecular sensing capabilities. The highly roughened gold region of the nanocoral increases the adsorption capacity and causes a strong surface‐enhanced Raman spectroscopy (SERS) signal. The polystyrene region can adsorb antibodies, allowing the nanocoral to specifically bind to receptors on the cancer cell membrane making nanocorals multifunctional nanosensors for cellular diagnostics and treatment evaluation.