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Nanopore Translocation and Force Spectroscopy Experiments in Microemulsion Droplets
Author(s) -
Renner Stephan,
Geltinger Sandra,
Simmel Friedrich C.
Publication year - 2010
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200901435
Subject(s) - nanopore , force spectroscopy , microemulsion , materials science , nanotechnology , spectroscopy , molecule , analyte , membrane , atomic force microscopy , analytical chemistry (journal) , chemical engineering , chemistry , chromatography , organic chemistry , physics , pulmonary surfactant , biochemistry , quantum mechanics , engineering
Nanopore translocation experiments are performed using a novel setup based on microemulsion droplets. This scales down the required analyte volume to only a few picoliters and provides very stable membranes for single‐molecule nanopore experiments. Using this setup, the stability of hairpin DNA and G‐quadruplex DNA is studied by nanopore force spectroscopy.