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Rattle‐Type Fe 3 O 4 @SiO 2 Hollow Mesoporous Spheres as Carriers for Drug Delivery
Author(s) -
Zhu Yufang,
Ikoma Toshiyuki,
Hanagata Nobutaka,
Kaskel Stefan
Publication year - 2010
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200901403
Subject(s) - mesoporous material , doxorubicin hydrochloride , cytotoxicity , materials science , nanoparticle , hela , spheres , mesoporous silica , particle size , nanotechnology , chemical engineering , drug carrier , particle (ecology) , nuclear chemistry , drug delivery , chemistry , doxorubicin , organic chemistry , in vitro , physics , biochemistry , oceanography , engineering , catalysis , medicine , surgery , chemotherapy , astronomy , geology
Rattle‐type Fe 3 O 4 @SiO 2 hollow mesoporous spheres with different particle sizes, different mesoporous shell thicknesses, and different levels of Fe 3 O 4 content are prepared by using carbon spheres as templates. The effects of particle size and concentration of Fe 3 O 4 @SiO 2 hollow mesoporous spheres on cell uptake and their in vitro cytotoxicity to HeLa cells are evaluated. The spheres exhibit relatively fast cell uptake. Concentrations of up to 150 µg mL −1 show no cytotoxicity, whereas a concentration of 200 µg mL −1 shows a small amount of cytotoxicity after 48 h of incubation. Doxorubicin hydrochloride (DOX), an anticancer drug, is loaded into the Fe 3 O 4 @SiO 2 hollow mesoporous spheres, and the DOX‐loaded spheres exhibit a somewhat higher cytotoxicity than free DOX. These results indicate the potential of Fe 3 O 4 @SiO 2 hollow mesoporous spheres for drug loading and delivery into cancer cells to induce cell death.